This is an informal analysis of the Iversen et al. study and a commentary on the piece, which was written in the BMJ (of all places). I did not take apart the statistical analysis of this article.
Autism spectrum disorder (ASD) is associated with profound dysfunction of the neurotransmitter system. The aberrant behavior, which theoretically correlates with poor functioning neurotransmitter includes anxiety, hyperactivity, aggression, obsessive-compulsive disorder, self-injury, and irritability. The focus of this evidence-based analysis compares the treatment protocols of serotonin re-uptake inhibitors (SSRIs) and N-acetylcysteine (NAC) in mitigating aberrant behavior in the ASD population.
Keywords: Cochrane, psychotropics, treatment adherence, public health surveillance, SSRI, autism, autistic spectrum disorder, prevalence, primary care, evidence base, review, trials, amino acid therapy, N-acetylcysteine, glutamate
Critical appraisal is a component of objective systematic investigation within the research literature with the purpose of forming an evidence-based opinion. Critical appraisal is the analysis of research methods and study results, which is necessary if an investigator wishes to establish validity regarding the author’s conclusions.